Tab Article
This book summarizes the results obtained by capillary electrophoresis (CE) using Capillarys 3 (Sebia) during phenotype studies of the different hemoglobin (Hb) disorders. Historically, studies of Hbs by liquid electrophoresis started in 1949 with Pauling revealing that the mobility of Hb S differed from that of Hb A. At this time only a very limited number of electrophoresis equipment, U-tubes type, was available and several hours were required to perform each analysis, a special optical device (Schlieren) was necessary to follow the electrophoretic separation of the Hb components and no quantitative measure was possible. This was only, and hardly, an analytical method.
Harshit Nahar
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